Waa maxay S-4 (Andrarine)

S-4, loo suuq geeyey sidaandarine, waa hab-nololeedka afka laga heli karo, oo aan isteeroydh-dooriyaha lahayn ee androgen receptor modulator (SARM).Andarine waa qayb ka mid ah agonist oo ka mid ah receptor androgen.

S-4 sida SARMS-yada kale ayaa la sameeyay horraantii 2000-meeyadii, iyada oo la isku dayay in laga gudbo xaddidaadaha dawooyinka iyo farmashiyaha ee steroidal androgen agonists (ie, testosterone iyo DHT), kuwaas oo loo yaqaan ururo leh beerka iyo cudurada wadnaha.

Compound S-4 ayaa loo isticmaalay daraasaadka xayawaanka laakiin waa laga tagay ka hor inta aan la gaarin waji kasta oo tijaabo caafimaad oo biniaadmi ah, sababo la xiriira naafonimada aragga.Saamayntani waxay dhacdaa marka molecule-ka S-4 uu ku xidho reseptors ee isha;Mar kasta oo ay ka sii daran tahay isku-xidhka, ayaa dhib badan oo la soo maray.Qalalaasaha aragga ayaa la ogaaday inay aad u badan yihiin, taasoo ay ugu wacan tahay fal farsamo oo gaar ah, oo loogu talagalay daawadii oo tijaabooyinkii laga tagay.

Sidee SameeS4Shaqada Andarine

Mid ka mid ah hababka la soo jeediyay eeS4, waa in ay gebi ahaanba xannibtay xidhitaanka DHT.Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5a-DHT, androstanolone ama stanolone) waa hoormoonka galmada ee androgen.Marka loo eego testosterone, DHT aad ayey uga awood badan tahay sida agonist ee soo-dhoweeyaha androgen.

S-4 waxay leedahay xiriiriye sare oo androgen (AR) ku xiran.Daraasaduhu waxay muujiyeen in S-4 ay ka awood yar tahay oo ka waxtar badan tahay testosterone propionate (TP) ee dhaqdhaqaaqa androgenic, laakiin hawlahooda anabolic waxay la mid yihiin ama ka weyn yihiin tan TP.

S-4 waa agonist buuxa androgen receptor agonist ee unugyada muruqa, iyo qayb ka mid ah agonist ee qanjirka 'prostate'.Sidaa darteed, S-4 waxay si xoog leh u kicisaa koritaanka murqaha, laakiin ma awoodo inay ilaaliso xajmiga qanjirka 'prostate'.Testosterone waxay kicisaa murqaha iyo korriinka qanjirka 'prostate' ilaa xad isku mid ah.S-4 waxay sababtaa hormoonka luteining-ka ee muhiimka ah (LH) ama xakamaynta hoormoonka kicinta follicle.

S-4 (andarine) Faa'iidooyinka

Inkasta oo daraasado badan oo baaris ah la sameeyay, cilmi-baaris dheeraad ah ayaa socota iyo marxaladaha hore ee horumarka.Horumarinta SARMS ee isticmaalka kiliinikada iyo daaweynta sida beddelka androgen, waa rajo ku salaysan xogta saxda ah.

Si ka duwan sida steroids anabolic, kuwaas oo ku xidhan soo-dhoweynta androgen ee unugyo badan oo jirka oo dhan ah, SARM-yada shakhsi ahaaneed waxay si xushmad leh ugu xidhaan daaweeyayaasha androgen ee unugyada qaarkood, laakiin maaha kuwa kale.Si kastaba ha ahaatee, waxay weli muujinayaan saamaynta androgenic iyo anabolic.

SARMS ma aha steroids anabolic;Halkii, ay yihiin ligands synthetic oo ku xidhan receptors androgen.Iyada oo ku xidhan qaab-dhismeedkooda molecular, waxay u dhaqmaan sida agonists, agonists qayb ah, iyo antagonists.Sidaas awgeed waa hab doorasho, in SARMS ay wax ka beddesho ama dhexdhexaadiso coregulators iyo qodobada qoraalka ama calaamadaynta borotiinka cascade si kor loogu qaado dhaqdhaqaaqa anabolic.

Daraasaduhu waxay muujiyeen S-4 waa agonist buuxa oo androgen agonist oo ku jira unugyada muruqa, iyo qayb ka mid ah agonist ee qanjirka 'prostate', taasoo ka dhigaysa musharax ku habboon sidii beddelka agonists-ka-qaadista steroidal androgen (ie, testosterone iyo DHT), sababtoo ah saameynaha xun ee la xidhiidha beerka, wadnaha, iyo bacriminta.

Waa in la ogaadaa, in kasta oo SARMS sida S4 ay kordhiso dhaqdhaqaaqa androgen, ma aha musharax macquul ah oo loogu talagalay daaweynta beddelka hoormoonka, maadaama aysan udgooneynin Estrogen.